ATG4C anticorps (C-Term)

N° du produit ABIN6992038

Cet anticorps Lapin Polyclonal détecte spécifiquement ATG4C dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATG4C anticorps (C-Term) (ABIN6992038)

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATG4C anticorps

Épitope: C-Term

Specificité: ATG4C antibody is human, mouse and rat reactive. ATG4C is predicted to not cross-react with other ATG4 proteins.

Purification: ATG4C antibody is affinity chromatography purified via peptide column.

Immunogène: ATG4C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4C. The immunogen is located within the last 50 amino acids of ATG4C.

Isotype: IgG

Information d'application

Indications d'application: ATG4C antibody can be used for detection of ATG4C by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG4C antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ATG4C antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur ATG4C

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Autre désignation: ATG4C

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein, all four are cysteine proteases (3). Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b, overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4).

Poids moléculaire: Predicted: 50 kDa

Observed: 57 kDa

ID gène: 84938

NCBI Accession: NP_835739

UniProt: Q96DT6

Pathways: Autophagy